Human papillomavirus prevalence and frequency of sexually transmitted diseases in encarcered women by self-sampling approach.

OBJECTIVE: This study aimed to assess the sociodemographic and clinical profile of women deprived of their liberty and to identify the prevalence of sexually transmitted diseases and human papillomavirus through self-sampling samples. METHODS: This is an epidemiological, cross-sectional, observational, and descriptive study of the prevalence and correlation of the diagnosis of human papillomavirus infection in 268 encarcered women in Amazonas submitted to self-sampling from June 2019 to September 2020 using the genotyping analysis. Patients with positive and inconclusive results were evaluated by commercialized PCR to detect pathogens causing sexually transmitted diseases. The sample size used was based on a convenience sample. RESULTS: In 268 women, human papillomavirus DNA was detected in 87 (32.5%) of them. Sexually transmitted diseases were detected in 30 (34.48%) of the 87 women with a positive or inconclusive result for human papillomavirus. Women with more than three pregnancies had a higher risk of human papillomavirus detection (p=0.004). CONCLUSION: The prevalence of human papillomavirus and other sexually transmitted diseases in encarcered women in Amazonas is 32.5 and 34.48%, respectively. Most women were single (60.4%) and reported having had more than 15 partners (90.8%).

Human papillomavirus prevalence and frequency of sexually transmitted diseases in encarcered women by self-sampling approach

SUMMARY OBJECTIVE: This study aimed to assess the sociodemographic and clinical profile of women deprived of their liberty and to identify the prevalence of sexually transmitted diseases and human papillomavirus through self-sampling samples. METHODS: This is an epidemiological, cross-sectional, observational, and descriptive study of the prevalence and correlation of the diagnosis of human papillomavirus infection in 268 encarcered women in Amazonas submitted to self-sampling from June 2019 to September 2020 using the genotyping analysis. Patients with positive and inconclusive results were evaluated by commercialized PCR to detect pathogens causing sexually transmitted diseases. The sample size used was based on a convenience sample. RESULTS: In 268 women, human papillomavirus DNA was detected in 87 (32.5%) of them. Sexually transmitted diseases were detected in 30 (34.48%) of the 87 women with a positive or inconclusive result for human papillomavirus. Women with more than three pregnancies had a higher risk of human papillomavirus detection (p=0.004). CONCLUSION: The prevalence of human papillomavirus and other sexually transmitted diseases in encarcered women in Amazonas is 32.5 and 34.48%, respectively. Most women were single (60.4%) and reported having had more than 15 partners (90.8%).

Qualidade de vida de mulheres mastectomizadas submetidas à reconstrução mamária imediata em hospital de referência oncológica no Amazonas: um estudo transversal / Quality of life of mastectomized women undergoing immediate breast reconstruction in a cancer referral hospital in Amazonas: a crosssectional study

Introdução: A avaliação da qualidade de vida é importante para uma abordagem mais humana e abrangente. Métodos: Trata-se de um estudo observacional transversal descritivo com abordagem quantitativa que avaliou a qualidade de vida em mulheres submetidas à reconstrução mamária imediata após a mastectomia, no período de janeiro a junho de 2015, na Fundação Centro de Controle de Oncologia do Amazonas. O instrumento de avaliação foi o questionário WHOQOL-bref, seguindo a sintaxe do Grupo WHOQOL. Resultados: Foram avaliadas 22 pacientes, em relação ao perfil sócio demográfico, a faixa etária predominante foi de 45 a 49 anos, o ensino médio foi o mais frequente no estudo (63,64%) e em relação a procedência 90,91% das pacientes foram de Manaus, quanto a estado civil 72,73% eram casadas. Na avaliação através do questionário, a autoavaliação de qualidade de vida foi definida como boa em 41%, o domínio físico apresentou o maior comprometimento, enquanto o domínio de relações sociais foi o menos afetado. Conclusão: A avaliação da qualidade de vida deve ser parte primordial na escolha do tratamento do câncer de mama.

Introduction: The assessment of the quality of life is considered important for a more humanistic and comprehensive treatment approach. Methods: This is a descriptive cross-sectional observational study using a quantitative approach. The quality of life of women undergoing immediate breast reconstruction after mastectomy at the Amazonas Oncology Control Center Foundation (Centro de Controle de Oncologia do Amazonas) from January to June 2015 was assessed. The assessment instrument used was the WHOQOL-BREF questionnaire, following the syntax of the WHOQOL Group. Results: The sociodemographic profiles of 22 patients were evaluated. The predominant age group was 45­49 years, the predominant educational level was high school (63.64%), 90.91% of the patients were from Manaus, and 72.73% were married. A total of 41% of the respondents defined their quality of life as good in the questionnaire, with the physical domain being the most affected and the social relationships domain being the less affected. Conclusion: The assessment of the quality of life should be prioritized in the choice of treatment for breast cancer.v

Epidemiological and clinical profile of men with breast cancer in Amazonas, Brazil / Perfil epidemiológico e clínico de homens com câncer de mama no Amazonas

The aim of the present study was to determine the epidemiological and clinical profile of men diagnosed with breast cancer at the Oncology Center Foundation (FCECON) of the state of Amazonas, Brazil. Male breast cancer is a rare disease, accounting for about 0.2% of all cancers, and it is responsible for 0.1% of male cancer deaths. Despite the rarity of the disease, statistics indicate that the incidence of male breast cancer has increased significantly from 0.86 to 1.06 per 100,000 men over the past 26 years. We conducted a retrospective longitudinal descriptive study of the medical records of male patients diagnosed with breast cancer from 2001 to 2013. In this study, there was a greater number of cases with ages over 55 years (83.54%), compared to an average age of 60­70 years reported in the literature. The histological type of the tumors analyzed was predominantly infiltrating ductal carcinoma (76.46%). We observed that tumors in stages IIIA and IIIB made up the majority of cases (58.82% in total), which was due to the patients' late search for medical care. There are no records of previous studies that address breast cancer in men in Amazonas, so we hope that our findings contribute relevant information about breast cancer in the state of Amazonas.

A presente pesquisa teve como objetivo conhecer o perfil epidemiológico e clínico de homens diagnosticados com câncer de mama na Fundação Centro de Oncologia (FCECON), do Amazonas. O câncer de mama masculino é uma doença rara, pois se apresenta em baixa frequência, representando 0,2% de todos os cânceres. É responsável por 0,1% das mortes por câncer no sexo masculino. Apesar da raridade da doença, estatísticas indicam que a incidência de câncer de mama masculino aumentou significativamente, de 0,86 a 1,06 por 100 mil homens ao longo dos últimos 26 anos. A proposta de estudo consistiu em uma pesquisa descritiva longitudinal retrospectiva, compor meio da análise de prontuários dos pacientes do sexo masculino diagnosticados com câncer de mama, no período de 2001 a 2013. Os trabalhos na literatura relatam idade média de 60 a 70 anos. Neste estudo, foi apresentado maior número de casos acima de 55 anos (83,54%). O tipo histológico dos tumores analisados foram predominantemente o carcinoma ductal infiltrante (76,46%). Neste trabalho, observou-se que os tumores em estágios IIIA e IIIB perfaziam a grande parte dos casos, 58,82% no total. Isso se deve à procura tardia dos pacientes por atendimento médico. Partindo do fato de que no estado do Amazonas não se encontraram registros de estudos anteriores que abordassem o câncer de mama em homens, como proposto por este trabalho, considera-se que a pesquisa pode somar esforços nessa empreitada. De forma mais específica, espera-se contribuir com informações qualificadas sobre o câncer de mama no estado Amazonas.

PROFILE OF CARE IN YOUNG WOMEN WITH BREAST CANCER IN AMAZONAS: 11 YEARS STUDY / Perfil de atendimento em mulheres jovens com câncer de mama no Amazonas: estudo de 11 anos

A cross-sectional, retrospective cohort study was carried out to describe the profile of breast cancer patients aged 40 years or less diagnosed and treated at the CECON/FCECON Foundation from 2003 to 2013. The following were evaluated: age, staging, place of origin and diagnostic accuracy, through search of records in patients' records. Data were computed in a database and analyzed through descriptive statistics. There were 211 patients under 40 years with breast cancer in the study period, representing 9.83%. The most affected age group was between 35 and 40 years. Regarding clinical staging, 57 cases were at stage IIA at diagnosis. About the method of screening, 71 patients performed it through clinical examination or self-examination and, in relation to the provenance, 48 cases were from other states. It is necessary to improve diagnosis in this age group and that the institutional care be directed to the patients of their original states

Um estudo de coorte retrospectivo, de corte transversal, foi realizado para descrever o perfil de pacientes com câncer de mama com 40 anos ou menos diagnosticados e tratados na Fundação CECON/FCECON de 2003 a 2013. Foram avaliados: idade, estadiamento, local de origem e acurácia diagnóstica, através da busca de registros nos prontuários dos pacientes. Os dados foram computados em um banco de dados e analisados por meio de análise estatística descritiva. Havia 211 pacientes com menos de 40 anos com câncer de mama no período do estudo, representando 9,83%. A faixa etária mais afetada foi entre 35 e 40 anos. Em relação ao estadiamento clínico, 57 casos estavam no estágio IIA no momento do diagnóstico. Sobre o método de triagem, 71 pacientes realizaram o exame clínico ou o autoexame, e em relação à procedência, 48 casos foram de outros estados. É necessário melhorar o diagnóstico nessa faixa etária e direcionar o cuidado institucional seja aos pacientes de seus estados originais.

Challenging Management of Hepatitis B infection in Ankylosing Spondylitis Patients in an Endemic Area during Immunosuppressive Therapy.

Hepatitis B infection is a global health issue. When considering patients with rheumatic diseases, this is no different. By using immunosuppressant drugs, such as DMARDs and biologics, viral reactivation is possible, leading to serious consequences on the patient. We report 3 cases of association between ankylosing spondylitis and hepatitis B with the use of immunosuppressant drugs. Case 1 was a patient with previous HBV infection using DMARD. Cases 2 and 3 were patients chronically infected by HBV during immunosuppressant therapy. The management of HBV infection during immunosuppressant therapy is challenging and needs multidisciplinary support.

Challenging management of hepatitis B infection in ankylosing spondylitis patients in an endemic area during immunosuppressive therapy

Abstract Hepatitis B infection is a global health issue. When considering patients with rheumatic diseases, this is no different. By using immunosuppressant drugs, such as DMARDs and biologics, viral reactivation is possible, leading to serious consequences on the patient. We report 3 cases of association between ankylosing spondylitis and hepatitis B with the use of immunosuppressant drugs. Case 1 was a patient with previous HBV infection using DMARD. Cases 2 and 3 were patients chronically infected by HBV during immunosuppressant therapy. The management of HBV infection during immunosuppressant therapy is challenging and needs multidisciplinary support.